Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro.

ABSTRACT:

Background

Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs, <10 nm) to nanosized (up to 50 nm) particles have vast applications in various biomedical areas including cancer treatment. The role of MVS-GNPs for inhibition of tumorigenic potential and stemness of glioma was investigated in this study.

Methods

Herein, MVS-GNPs synthesized and characterized by means of X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) techniques. Afterwards, interaction of these GNPs

SUBMITTER: Wahab R 

PROVIDER: S-EPMC6391154 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature