Characterization, optimization, and in vitro evaluation of Technetium-99m-labeled niosomes.

ABSTRACT:

Background and purpose

Niosomes are nonionic surfactant-based vesicles that exhibit certain unique features which make them favorable nanocarriers for sustained drug delivery in cancer therapy. Biodistribution studies are critical in assessing if a nanocarrier system has preferential accumulation in a tumor by enhanced permeability and retention effect. Radiolabeling of nanocarriers with radioisotopes such as Technetium-99m (^99mTc) will allow for the tracking of the nanocarrier noninvasively via nuclear imaging. The purpose of this study was to formulate, characterize, and optimize ^99mTc-labeled niosomes.

Methods

Niosomes were prepared from a mixture of sorbitan monostearate 60, cholesterol, and synthesized D-α-tocopherol polyethylene glycol 1000 succin

SUBMITTER: De Silva L 

PROVIDER: S-EPMC6391155 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature