Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.

ABSTRACT:

Importance

Perimenopause is accompanied by an increased risk of new and recurrent depression. The coincidence of declining ovarian function with the onset of depression led to the inference that "withdrawal" from physiologic estradiol levels underpinned depression in perimenopause. To our knowledge, this is the first controlled systematic study to directly test the estrogen withdrawal theory of perimenopausal depression (PMD).

Objective

To examine the role of estradiol withdrawal in PMD.

Design, setting, and participants

Initial open-label treatment with estradiol followed by randomized, double-blind, placebo-controlled, parallel-design evaluation of continued estradiol treatment was evaluated at an outpatient research facility at the National Institutes of Health Cli

SUBMITTER: Schmidt PJ 

PROVIDER: S-EPMC6391160 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature