Genetic variants associated with patent ductus arteriosus in extremely preterm infants.

ABSTRACT:

Objective

Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants.

Study design

Preterm infants (n = 1013) enrolled at NICHD Neonatal Research Network sites were phenotyped for PDA. DNA was genotyped for 1634 single nucleotide polymorphisms (SNPs) from candidate genes. Analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables.

Results

SNPs in several genes were associated with the clinical diagnosis of PDA and with surgical ligation in extremely preterm neonates diagnose

SUBMITTER: Dagle JM 

PROVIDER: S-EPMC6391165 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature