Predicting extinction phenotype to optimize fear reduction.

ABSTRACT: Fear conditioning is widely employed to study dysregulations of the fear system. The repeated presentation of a conditioned stimulus in the absence of a reinforcer leads to a decrease in fear responding-a phenomenon known as extinction. From a translational perspective, identifying whether an individual might respond well to extinction prior to intervention could prove important to treatment outcomes. Here, we test the hypothesis that CO₂ reactivity predicts extinction phenotype in rats, and that variability in CO₂ reactivity as well as extinction long-term memory (LTM) significantly predicts orexin activity in the lateral hypothalamus (LH). Our results validate a rat model of CO₂ reactivity and show that subcomponents of behavioral reactivity following acu

SUBMITTER: Monfils MH 

PROVIDER: S-EPMC6391193 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature