Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.

ABSTRACT: Despite a growing body of knowledge about the genomic landscape and molecular pathogenesis of sarcomas, translation of basic discoveries into targeted therapies and significant clinical gains has remained elusive. Renewed interest in altered metabolic properties of cancer cells has led to an exploration of targeting metabolic dependencies as a novel therapeutic strategy. In this study, we have characterized the dependency of human pediatric sarcoma cells on key metabolic substrates and identified a mechanism of adaptation to metabolic stress by examining proliferation and bioenergetic properties of rhabdomyosarcoma and Ewing sarcoma cells under varying concentrations of glucose and glutamine. While all cell lines tested were completely growth-inhibited by lack of glucose, cells adapted to

SUBMITTER: Issaq SH 

PROVIDER: S-EPMC6391386 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature