Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres.

ABSTRACT: The dystrophin-glycoprotein complex (DGC) links the muscle cytoskeleton to the extracellular matrix and is responsible for force transduction and protects the muscle fibres from contraction induced damage. Mutations in components of the DGC are responsible for muscular dystrophies and congenital myopathies. Expression of DGC components have been shown to be altered in many myopathies. In contrast we have very little evidence of whether adaptive changes in muscle impact on DGC expression. In this study we investigated connection between muscle fibre phenotype and the DGC. Our study reveals that the levels of DGC proteins at the sarcolemma differ in highly glycolytic muscle compared to wild-type and that these changes can be normalised by the super-imposition of an oxidative metabolic progra

SUBMITTER: Omairi S 

PROVIDER: S-EPMC6391483 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature