High-speed scanning of planar images showing ¹²³I-MIBG uptake using a whole-body CZT camera: a phantom and clinical study.

ABSTRACT:

Background

The heart-to-mediastinum ratio (HMR) obtained in myocardial sympathetic innervation imaging using ¹²³I-metaiodobenzylguanidine (MIBG) is used for heart failure or Lewy body diseases (LBD). Discovery NM/CT 670 CZT, a novel whole-body scanner, enables direct HMR measurements in planar images, in contrast to cardiac-dedicated CZT-based cameras which require specific post-processing reconstruction. We sought to investigate the clinical utility of the Discovery NM/CT 670 CZT for myocardial innervation imaging and the potential time reduction.

Results

Following preliminary phantom examinations, ¹²³I-MIBG planar imaging was performed in 36 patients with suspected or known LBD to measure HMRs with a collection time of 300 s. Images for different coll

SUBMITTER: Okano N 

PROVIDER: S-EPMC6391509 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature