ELMO1 deficiency enhances platelet function.

ABSTRACT: Phosphatidylinositol 3-kinase is an important signaling molecule that, once activated, leads to the generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP₃). We performed a proteomic screen to identify PIP₃-interacting proteins in human platelets_. Among these proteins, we found engulfment and cell motility 1 (ELMO1), a scaffold protein with no catalytic activity. ELMO1 is expressed in platelets and interacts with active RhoG. However, the function of ELMO1 in platelets is not known. The focus of this study was to determine the function of ELMO1 in platelets utilizing ELMO1^-/- mice. Platelet aggregation, granule secretion, integrin αIIbβ3 activation, and thromboxane generation were enhanced in ELMO1^-/- platelets in response to gl

SUBMITTER: Patel A 

PROVIDER: S-EPMC6391667 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature