Progression of mycosis fungoides occurs through divergence of tumor immunophenotype by differential expression of HLA-DR.

ABSTRACT: Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4⁺ T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage. We obtained skin biopsies and blood from 43 patients with CD4⁺ MF and undertook a detailed phenotypic and functional analysis of CD4⁺ and CD8⁺ T cells. Clonotypic TCRBV staining allowed delineation of malignant and reactive

SUBMITTER: Murray D 

PROVIDER: S-EPMC6391678 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature