Divergent hypersensitivity responses following topical application of the quaternary ammonium compound, didecyldimethylammonium bromide.

ABSTRACT: Didecyldimethylammonium bromide (DDAB) is a fourth generation dialkyl-quaternary ammonium compound (QAC) that is used in numerous products for its antimicrobial properties. While many QACs have been associated with allergic disease, the toxicity and sensitization of DDAB have not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of DDAB following dermal application in a murine model. DDAB induced significant irritancy (0.0625-2%), evaluated by ear swelling in female BALB/c mice. Initial evaluation of the sensitization potential was conducted using the local lymph node assay (LLNA) at concentrations ranging from 0.0625% to 2%. A concentration-dependent increase in lymphocyte proliferation was observed with a calculated EC3 v

SUBMITTER: Shane HL 

PROVIDER: S-EPMC6391722 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature