Reward-circuit biomarkers of risk and resilience in adolescent depression.

ABSTRACT:

Background

Dysfunctional reward processing is a core feature of major depressive disorder. While there is growing knowledge of reward processing in adolescent depression, researchers have ignored neural mechanisms of resilience to depression. Here, we examine neural correlates of reward processing that characterize resilience and risk in adolescents at risk for depression, facilitating the development of effective intervention approaches that strengthen resilience to psychopathology in at-risk youth.

Methods

50 adolescent females were followed through age 18: 32 at-risk adolescents who either did (remitted-depressed; n = 15) or did not (resilient; n = 17) experience a depressive episode, and 18 low-risk healthy controls. Participants completed clinical assessments at 18-mont

SUBMITTER: Fischer AS 

PROVIDER: S-EPMC6391738 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature