Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice.

ABSTRACT:

Purpose

Astronauts traveling beyond low-Earth orbit will be exposed to high linear-energy transfer charged particles. Because there is concern about the adverse effects of space radiation on the cardiovascular system, this study assessed cardiac function and structure and immune cell infiltration in a mouse model of charged-particle irradiation.

Materials and methods

Male C57BL/6 J mice were exposed to oxygen ions (¹⁶O, 600 MeV/n at 0.25-0.26 Gy/min to a total dose of 0, 0.05, 0.1, 0.25, or 1 Gy), protons (150 MeV, 0.35-0.55 Gy/min to 0, 0.5, or 1 Gy), or protons (150 MeV, 0.5 Gy) followed by ¹⁶O (600 MeV/n, 0.1 Gy). Separate groups of mice received ¹³⁷Cs γ-rays (1 Gy/min to 0, 0.5, 1, or 3 Gy) as a reference. Cardiac function and blood veloc

SUBMITTER: Seawright JW 

PROVIDER: S-EPMC6391741 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature