Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and bla_NDM gene in Enterobacteriaceae causing neonatal septicaemia.

ABSTRACT:

Background

The bla_NDM-1 (New Delhi Metallo-β-lactamase-1) gene has disseminated around the globe. NDM-1 producers are found to co-harbour resistance genes against many antimicrobials, including fluoroquinolones. The spread of large plasmids, carrying both bla_NDM and plasmid-mediated fluoroquinolone resistance (PMQR) markers, is one of the main reasons for the failure of these essential antimicrobials.

Methods

Enterobacteriaceae (n = 73) isolated from the blood of septicaemic neonates, admitted at a neonatal intensive care unit (NICU) in Kolkata, India, were identified followed by PFGE, antibiotic susceptibility testing and determination of MIC values for meropenem and ciprofloxacin. Metallo-β-lactamases and PMQRs were identif

SUBMITTER: Mitra S 

PROVIDER: S-EPMC6391786 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature