Jaw osteosarcoma models in mice: first description.

ABSTRACT:

Background

Osteosarcoma (OS) is the most common cancer of bone. Jaw osteosarcoma (JOS) is rare and it differs from other OS in terms of the time of occurrence (two decades later) and better survival. The aim of our work was to develop and characterize specific mouse models of JOS.

Methods

Syngenic and xenogenic models of JOS were developed in mice using mouse (MOS-J) and human (HOS1544) osteosarcoma cell lines, respectively. An orthotopic patient-derived xenograft model (PDX) was also developed from a mandibular biopsy. These models were characterized at the histological and micro-CT imaging levels, as well as in terms of tumor growth and metastatic spread.

Results

Homogeneous tumor growth was observed in both the HOS1544 and the MOS-J JOS models by injection of 0.25 

SUBMITTER: Bertin H 

PROVIDER: S-EPMC6391788 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature