Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia.

ABSTRACT:

Objectives

To examine the cross-sectional association between functional performance and Alzheimer's disease (AD) neuroimaging biomarkers in individuals without dementia (cognitively unimpaired (CU), and those with mild cognitive impairment (MCI)).

Design

Cross-sectional.

Setting

Olmsted County, Minnesota.

Participants

Population-based Mayo Clinic Study of Aging (MCSA) participants (aged ≥ 50, mean age 71.3 ± 10.2; 53.4% male; 28.3% apolipoprotein (APO)E ε4 allele carriers, 1,578 CU, 204 MCI) who underwent ¹¹ C-Pittsburgh compound B (¹¹ C-PiB) positron emission tomography (PET) (N=1,782).

Measurements

We defined an abnormal (high) ¹¹ C-PiB-PET retention ratio as a standardized uptake value ratio greater than 1.42 (high am

SUBMITTER: Vassilaki M 

PROVIDER: S-EPMC6391872 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature