Altered cord blood mitochondrial DNA content and pregnancy lead exposure in the PROGRESS cohort.

ABSTRACT:

Introduction

Lead (Pb) crosses the placenta and can cause oxidative stress, reduced fetal growth and neurological problems. The principal source of oxidative stress in human cells is mitochondria. Therefore, disruption of normal mitochondrial function during pregnancy may represent a primary mechanism behind the adverse effects of lead. We sought to assess the association of Pb exposure during pregnancy with mitochondrial DNA (mtDNA) content, a sensitive marker of mitochondrial function, in cord blood.

Materials and methods

This study comprised mother-infant pairs from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study, a prospective birth-cohort that enrolled 1050 pregnant women from Mexico City who were receiving prenatal care be

SUBMITTER: Sanchez-Guerra M 

PROVIDER: S-EPMC6391888 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature