Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes.

ABSTRACT: Intracortical microelectrodes exhibit enormous potential for researching the nervous system, steering assistive devices and functional electrode stimulation systems for severely paralyzed individuals, and augmenting the brain with computing power. Unfortunately, intracortical microelectrodes often fail to consistently record signals over clinically useful periods. Biological mechanisms, such as the foreign body response to intracortical microelectrodes and self-perpetuating neuroinflammatory cascades, contribute to the inconsistencies and decline in recording performance. Unfortunately, few studies have directly correlated microelectrode performance with the neuroinflammatory response to the implanted devices. However, of those select studies that have, the role of the innate immune system

SUBMITTER: Hermann JK 

PROVIDER: S-EPMC6391891 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature