The H₂S-Releasing Naproxen Derivative ATB-346 and the Slow-Release H₂S Donor GYY4137 Reduce Intestinal Inflammation and Restore Transit in Postoperative Ileus.

ABSTRACT: Objective: Intestinal inflammation triggers postoperative ileus (POI), commonly seen after abdominal surgery and characterized by impaired gastrointestinal transit; when prolonged, this leads to increased morbidity. Hydrogen sulfide (H₂S) is recognized as an important mediator of many (patho)physiological processes, including inflammation, and is now investigated for anti-inflammatory application. Therefore, the aim of this study was to investigate the effect of the H₂S-releasing naproxen derivative ATB-346, developed to reduce gastrointestinal injury by naproxen, and the slow-release H₂S donor GYY4137 on intestinal inflammation and delayed gastrointestinal transit in murine POI. Methods: C57Bl6J mice were fasted for 6 h, anesthetized and afte

SUBMITTER: Van Dingenen J 

PROVIDER: S-EPMC6391894 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature