Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants.

ABSTRACT:

Background

Micronutrient deficiencies may contribute to reduced oral vaccine immunogenicity in developing countries. We hypothesised that neonatal vitamin A supplementation (NVAS) would improve oral vaccine responses.

Methods

We performed a cross-sectional study of infants recruited at birth to the Zimbabwe Vitamin A for Mothers and Babies (ZVITAMBO) trial, a randomised controlled trial of single, high-dose NVAS vs placebo conducted in Zimbabwe between 1997-2001. We measured poliovirus-specific IgA to type 1-3 polio strains by semiquantitative capture ELISA in cryopreserved plasma samples collected at 6 months of age.

Results

A total of 181 infants fulfilled inclusion criteria, of whom 80 were randomised to NVAS and 101 to placebo. There were no significant difference

SUBMITTER: Church JA 

PROVIDER: S-EPMC6391935 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature