Catalytic Isohypsic-Redox Sequences for the Rapid Generation of C_sp3 -Containing Heterocycles.

ABSTRACT: Cross-coupling reactions catalyzed by transition metals are among the most influential in modern synthetic chemistry. The vast majority of transition-metal-catalyzed cross-couplings rely on a catalytic cycle involving alternating oxidation and reduction of the metal center and are generally limited to forging just one type of new bond per reaction (e.g., the biaryl linkage formed during a Suzuki cross-coupling). This work presents an Isohypsic-Redox Sequence (IRS) that uses one metal to effect two catalytic cycles, thereby generating multiple new types of bonds from a single catalyst source. We show that the IRS strategy is amenable to several widely used transformations including the Suzuki-Miyaura coupling, Buchwald-Hartwig amination, and Wacker oxidation. Furthermore, each of these reac

SUBMITTER: Smith CD 

PROVIDER: S-EPMC6391974 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature