Lipoprotein-associated phospholipase A₂ and risk of incident peripheral arterial disease: Findings from The Atherosclerosis Risk in Communities study (ARIC).

ABSTRACT:

Background and aims

Results from prospective studies evaluating the relationship between elevated lipoprotein-associated phospholipase A₂ (Lp-PLA₂) activity and incident peripheral arterial disease (PAD) have been mixed. We investigated whether higher Lp-PLA₂ levels are associated with increased risk of incident PAD and whether PLA2G7 gene variants, which result in lower Lp-PLA₂ levels, are associated with reduced risk of incident PAD.

Methods

Our analysis included 9922 participants (56% female; 21% African-American; mean age 63 years) without baseline PAD at ARIC Visit 4 (1996-1998), who had Lp-PLA₂ activity measured and were subsequently followed for the development of PAD, defined by occurrence of a PAD-related hospit

SUBMITTER: Garg PK 

PROVIDER: S-EPMC6392003 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature