Behavioral profiles in Rett syndrome: Data from the natural history study.

ABSTRACT:

Introduction

Rett syndrome (RTT) is a complex neurodevelopmental disorder with known behavioral abnormalities, both internalizing (e.g., anxiety, social withdrawal) and externalizing (e.g., aggression, self-abuse). However, a broad evaluation of behavioral abnormalities in a large cohort is lacking.

Objective

In this report, we describe profiles of internalizing and externalizing behaviors in individuals evaluated in the multi-center U.S. Rett Natural History Study.

Methods

Cross-sectional and longitudinal data were collected from 861 females with RTT and from 48 females who have MECP2 mutations without meeting criteria for RTT. Standard statistical methods including linear regression evaluated internalizing behavioral components from the Child Health Questionnaire (C

SUBMITTER: Buchanan CB 

PROVIDER: S-EPMC6392009 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature