Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging.

ABSTRACT: Magnetic nanoparticles (MNPs) have been extensively explored as magnetic resonance imaging (MRI) contrast agents. With the increasing complexity in the structure of modern MNPs, the classical Solomon-Bloembergen-Morgan and the outer-sphere quantum mechanical theories established on simplistic models have encountered limitations for defining the emergent phenomena of relaxation enhancement in MRI. Recent progress in probing MRI relaxivity of MNPs based on structural features at the molecular and atomic scales is reviewed, namely, the structure-relaxivity relationships, including size, shape, crystal structure, surface modification, and assembled structure. A special emphasis is placed on bridging the gaps between classical simplistic models and modern MNPs with elegant structural complexity

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC6392011 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature