Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer.

ABSTRACT:

Background

Higher intake of marine n-3 (also called omega-3) fatty acids has been associated with reduced risks of cardiovascular disease and cancer in several observational studies. Whether supplementation with n-3 fatty acids has such effects in general populations at usual risk for these end points is unclear.

Methods

We conducted a randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D₃ (at a dose of 2000 IU per day) and marine n-3 fatty acids (at a dose of 1 g per day) in the primary prevention of cardiovascular disease and cancer among men 50 years of age or older and women 55 years of age or older in the United States. Primary end points were major cardiovascular events (a composite of myocardial infarction, stroke, or death

SUBMITTER: Manson JE 

PROVIDER: S-EPMC6392053 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature