Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation.

ABSTRACT: Eukaryotic translation initiation factor 4E (eIF4E) is a key player in the initiation of cap-dependent translation through recognition of the m⁷GpppX cap at the 5' terminus of coding mRNAs. As eIF4E overexpression has been observed in a number of human diseases, most notably cancer, targeting this oncogenic translation initiation factor has emerged as a promising strategy for the development of novel anti-cancer therapeutics. Toward this end, in the present study, we have rationally designed a series of Bn⁷GxP-based PROTACs for the targeted degradation of eIF4E. Herein we describe our synthetic efforts, in addition to biochemical and cellular characterization of these compounds.

SUBMITTER: Kaur T 

PROVIDER: S-EPMC6392074 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature