Generation and Immune Regulation of CD4⁺CD25^-Foxp3⁺ T Cells in Chronic Obstructive Pulmonary Disease.

ABSTRACT: The imbalance of CD4⁺Foxp3⁺ T cell subsets is reportedly involved in abnormal inflammatory immune responses in patients with chronic obstructive pulmonary disease (COPD). However, the possible role of CD4⁺CD25^-Foxp3⁺ T cells in immune regulation in COPD remains to be investigated. In the current study, distribution and phenotypic characteristics of CD4⁺CD25^-Foxp3⁺ T cells from peripheral blood were determined by flow cytometry; the origin, immune function and ultimate fate of CD4⁺CD25^-Foxp3⁺ T cells were further explored in vitro. It was observed that circulating CD4⁺CD25^-Foxp3⁺ T cells were significantly increased in stable COPD p

SUBMITTER: Wu JH 

PROVIDER: S-EPMC6392103 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature