Sex- and age-based differences in the natural history and outcome of dilated cardiomyopathy.

ABSTRACT:

Aim

To evaluate the relationship between sex, age and outcome in dilated cardiomyopathy (DCM).

Methods and results

We used proportional hazard modelling to examine the association between sex, age and all-cause mortality in consecutive patients with DCM. Overall, 881 patients (290 women, median age 52 years) were followed for a median of 4.9 years. Women were more likely to present with heart failure (64.0% vs. 54.5%; P = 0.007) and had more severe symptoms (P < 0.0001) compared to men. Women had smaller left ventricular end-diastolic volume (125 mL/m² vs. 135 mL/m² ; P < 0.001), higher left ventricular ejection fraction (40.2% vs. 37.9%; P = 0.019) and were less likely to have mid-wall late gadolinium enhancement (23.0% vs. 38.9%; P < 0.0001). During f

SUBMITTER: Halliday BP 

PROVIDER: S-EPMC6392171 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature