Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling.

ABSTRACT:

Background and purpose

Recent studies have shown that the cellular immune response in the development of vascular remodeling modulates the resulting pathological alterations. We show that hypoxia-inducible factor 1 (Hif-1) (specifically expressed in T cells) is involved in the immune response to vascular remodeling that accompanies arteriosclerosis.

Methods and results

To study the role of T cells in the development of vascular remodeling, femoral arterial injury induced by an external vascular polyethylene cuff was examined in mice lacking Hif-1 (specifically in T cells). We found that cuff placement caused prominent neointimal hyperplasia of the femoral artery in Hif-1- (T-cell)-deficient mice compared with that in control mice and that infiltration of inflammatory cells a

SUBMITTER: Kurobe H 

PROVIDER: S-EPMC6392182 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature