Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei.

ABSTRACT: OBJECTIVE:To look for abnormalities in circulating B-cell subsets in patients with rheumatic symptoms of Whipple's disease (WD). METHOD:Consecutive patients seen between 2010 and 2016 for suspected inflammatory joint disease were identified retrospectively. Results of standardized immunological and serological tests and of peripheral-blood B-cell and T-cell subset analysis by flow cytometry were collected. Patients with criteria suggesting WD underwent PCR testing for Tropheryma whipplei, and those with diagnosis of WD (cases) were compared to those without diagnosis (controls). We used ROC curve analysis to evaluate the diagnostic value of flow cytometry findings for WD. RESULTS:Among 2917 patients seen for suspected inflammatory joint disease, 121 had suspected WD, including 9 (9/121, 7.

SUBMITTER: Le Goff M 

PROVIDER: S-EPMC6392227 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature