Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulation.

ABSTRACT: In the present study, we investigated the capabilities of a novel ultrasonic approach for real-time control of fibrinolysis under flow conditions. Ultrasonic monitoring was performed in a specially designed experimental in vitro system. Fibrinolytic agents were automatically injected at ultrasonically determined stages of the blood clotting. The following clots dissolution in the system was investigated by means of ultrasonic monitoring. It was shown, that clots resistance to fibrinolysis significantly increases during the first 5 minutes since the formation of primary micro-clots. The efficiency of clot lysis strongly depends on the concentration of the fibrinolytic agent as well as the delay of its injection moment. The ultrasonic method was able to detect the coagulation at early stages

SUBMITTER: Ivlev DA 

PROVIDER: S-EPMC6392241 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature