A case-control study of trace-element status and lung cancer in Appalachian Kentucky.

ABSTRACT: Appalachian Kentucky (App KY) leads the nation in lung cancer incidence and mortality. Trace elements, such as As, have been associated with lung cancers in other regions of the country and we hypothesized that a population-based study would reveal higher trace element concentrations in App KY individuals with cancer compared to controls. Using toenail and drinking water trace element concentrations, this study investigated a possible association between lung cancer incidence and trace-element exposure in residents of this region. This population-based case-control study had 520 subjects, and 367 subjects provided toenail samples. Additionally, we explored the relationship between toenail and fingernail trace-element concentrations to determine if fingernails could be used as a surrogate f

SUBMITTER: Unrine JM 

PROVIDER: S-EPMC6392268 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature