Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults.

ABSTRACT: BACKGROUND:Arterial stiffness independently predicts cardiovascular disease. However, few studies have evaluated the associations of central and peripheral pulse wave velocity (PWV) with biomarkers of both myocardial stress (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin-T [hs-cTnT]) among persons without cardiac disease. METHODS:We examined 3,348 participants (67-90 years) without prevalent cardiac disease in the Atherosclerosis Risk in Communities (ARIC) Study (2011-13). The cross-sectional associations of PWV quartiles for central arterial segments (carotid-femoral, heart-carotid, heart-femoral) and peripheral artery (femoral-ankle) with NT-proBNP and hs-cTnT were evaluated accounting for potential confounders. RESULTS:Most PWV measures demonstrated J- or

SUBMITTER: Liu S 

PROVIDER: S-EPMC6392306 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature