Intra-amniotic Ureaplasma parvum-Induced Maternal and Fetal Inflammation and Immune Responses in Rhesus Macaques.

ABSTRACT:

Background

Although Ureaplasma species are the most common organisms associated with prematurity, their effects on the maternal and fetal immune system remain poorly characterized.

Methods

Rhesus macaque dams at approximately 80% gestation were injected intra-amniotically with 10⁷ colony-forming units of Ureaplasma parvum or saline (control). Fetuses were delivered surgically 3 or 7 days later. We performed comprehensive assessments of inflammation and immune effects in multiple fetal and maternal tissues.

Results

Although U. parvum grew well in amniotic fluid, there was minimal chorioamnionitis. U. parvum colonized the fetal lung, but fetal systemic microbial invasion was limited. Fetal lung inflammation was mild, with elevations in CXCL8, tumor necrosis f

SUBMITTER: Senthamaraikannan P 

PROVIDER: S-EPMC6392471 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature