Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice.

ABSTRACT:

Objective

Recombinant inbred mouse strains generated from an LG/J and SM/J intercross offer a unique resource to study complex genetic traits such as osteoarthritis (OA). We undertook this study to determine the susceptibility of 14 strains to various phenotypes characteristic of posttraumatic OA. We hypothesized that phenotypic variability is associated with genetic variability.

Methods

Ten-week-old male mice underwent surgical destabilization of the medial meniscus (DMM) to induce posttraumatic OA. Mice were killed 8 weeks after surgery, and knee joints were processed for histology to score cartilage degeneration and synovitis. Micro-computed tomography was used to analyze trabecular bone parameters including subchondral bone plate thickness and synovial ectopic calcificat

SUBMITTER: Chinzei N 

PROVIDER: S-EPMC6393186 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature