A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis.

ABSTRACT: The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. MIG-6 mediates P4 signaling and acts as a tumor suppressor during endometrial tumorigenesis in both humans and mice. In previous studies, we developed the conditional knockout of Mig-6 in all uterine compartments (Pgr^cre/+Mig-6^f/f; Mig-6^KO) and endometrial epithelial cell-specific Mig-6 knockout (Sprr2f^cre/+Mig-6^f/f; Mig-6^Ep-KO) mice. Both mouse models developed endometrial hyperplasia and E2-dependent endometrial cancer. P4 tre

SUBMITTER: Teasley HE 

PROVIDER: S-EPMC6393191 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature