Altered Cervical Spinal Cord Resting-State Activity in Fibromyalgia.

ABSTRACT:

Objective

Altered afferent input and central neural modulation are thought to contribute to fibromyalgia symptoms, and these processes converge within the spinal cord. We undertook this study to investigate the hypothesis that, using resting-state functional magnetic resonance imaging (rs-fMRI) of the cervical spinal cord, we would observe altered frequency-dependent activity in fibromyalgia.

Methods

Cervical spinal cord rs-fMRI was conducted in fibromyalgia patients (n = 16) and healthy controls (n = 17). We analyzed the amplitude of low-frequency fluctuations (ALFF), a measure of low-frequency oscillatory power, for frequencies of 0.01-0.198 Hz and frequency sub-bands to determine regional and frequency-specific alterations in fibromyalgia. Functional connectivity and grap

SUBMITTER: Martucci KT 

PROVIDER: S-EPMC6393192 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature