Beyond Pathway Analysis: Identification of Active Subnetworks in Rett Syndrome.

ABSTRACT: Pathway and network approaches are valuable tools in analysis and interpretation of large complex omics data. Even in the field of rare diseases, like Rett syndrome, omics data are available, and the maximum use of such data requires sophisticated tools for comprehensive analysis and visualization of the results. Pathway analysis with differential gene expression data has proven to be extremely successful in identifying affected processes in disease conditions. In this type of analysis, pathways from different databases like WikiPathways and Reactome are used as separate, independent entities. Here, we show for the first time how these pathway models can be used and integrated into one large network using the WikiPathways RDF containing all human WikiPathways and Reactome pathways, to perf

SUBMITTER: Miller RA 

PROVIDER: S-EPMC6393361 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature