Reimplantable Microdrive for Long-Term Chronic Extracellular Recordings in Freely Moving Rats.

ABSTRACT: Extracellular recordings of electrical activity in freely moving rats are fundamental to understand brain function in health and disease. Such recordings require a small-size, lightweight device that includes movable electrodes (microdrive) to record either a new set of neurons every day or the same set of neurons over time. Ideally, microdrives should be easy to implant, allowing precise and smooth displacement of electrodes. The main caveat of most commercially available microdrives is their relatively short half-life span, in average ranging from weeks to a month. For most experiments, recording days-weeks is sufficient, but when the experiment depends on training animals for several months, it is crucial to develop new approaches. Here, we present a low-cost, reusable, and reimplantabl

SUBMITTER: Polo-Castillo LE 

PROVIDER: S-EPMC6393392 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature