Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.

ABSTRACT: Lactobacilli have been evaluated as probiotics against Candida infections in several clinical trials, but with variable results. Predicting and understanding the clinical efficacy of Lactobacillus strains is hampered by an overall lack of insights into their modes of action. In this study, we aimed to unravel molecular mechanisms underlying the inhibitory effects of lactobacilli on hyphal morphogenesis, which is a crucial step in C. albicans virulence. Based on a screening of different Lactobacillus strains, we found that the closely related taxa L. rhamnosus, L. casei and L. paracasei showed stronger activity against Candida hyphae formation compared to other Lactobacillus species tested. By exploring the activity of purified compounds and mutants of the model strain L. rhamnosus GG, the

SUBMITTER: Allonsius CN 

PROVIDER: S-EPMC6393446 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature