Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia.

ABSTRACT: Cognitive deficits are considered a core component of schizophrenia and may predict functional outcome. However, the neural underpinnings of neuropsychological impairment remain to be fully elucidated. Data of 59 schizophrenia patients and 72 healthy controls from a public resting-state fMRI database was employed in our study. Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Battery was used to measure deficits of cognitive abilities in schizophrenia. Neural correlates of cognitive deficits in schizophrenia were examined by linear regression analysis of the thalamocortical network activity with scores of seven cognitive domains. We confirmed the combination of reduced prefrontal-thalamic connectivity and increased sensorimotor-thalamic connectivity in pati

SUBMITTER: Chen P 

PROVIDER: S-EPMC6393449 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature