Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.

ABSTRACT: The pressure towards innovation and creation of new model systems in regenerative medicine and cancer research has fostered the development of novel potential therapeutic applications. Kidney injuries provoke a high request of organ transplants making it the most demanding system in the field of regenerative medicine. Furthermore, renal cancer frequently threaten patients' life and aggressive forms still remain difficult to treat. Ethical issues related to the use of embryonic stem cells, has fueled research on adult, patient-specific pluripotent stem cells as a model for discovery and therapeutic development, but to date, normal and cancerous renal experimental models are lacking. Several research groups are focusing on the development of organoid cultures. Since organoids mimic the origi

SUBMITTER: Grassi L 

PROVIDER: S-EPMC6393468 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature