Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload.

ABSTRACT: Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. However, recent evidence suggests that AVR outcome can be improved if performed earlier. After AVR, the process of left ventricle (LV) reverse remodelling (RR) is variable and frequently incomplete. In this study, we aimed at detecting mechanism underlying the process of LV RR regarding myocardial structural, functional and molecular changes before the onset of HF symptoms. Wistar-Han rats were subjected to 7-weeks of ascending aortic-banding followed by a 2-week period of debanding to resemble AS-induced LV remodelling and the early events of AVR-induced RR, respectively. This resulted in

SUBMITTER: Miranda-Silva D 

PROVIDER: S-EPMC6393473 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature