Discordant attributes of structural and functional brain connectivity in a two-layer multiplex network.

ABSTRACT: Several studies have suggested that functional connectivity (FC) is constrained by the underlying structural connectivity (SC) and mutually correlated. However, not many studies have focused on differences in the network organization of SC and FC, and on how these differences may inform us about their mutual interaction. To explore this issue, we adopt a multi-layer framework, with SC and FC, constructed using Magnetic Resonance Imaging (MRI) data from the Human Connectome Project, forming a two-layer multiplex network. In particular, we examine node strength assortativity within and between the SC and FC layer. We find that, in general, SC is organized assortatively, indicating brain regions are on average connected to other brain regions with similar node strengths. On the other hand, FC

SUBMITTER: Lim S 

PROVIDER: S-EPMC6393555 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature