Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology.

ABSTRACT:

Objectives

To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology.

Methods

We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, direct medical costs, quality-adjusted life years (QALYs) and the incremental cost-effectiveness analysis of two strategies from the healthcare payer perspective. The study population is a cohort of women 30-65 years of age presenting for cervical screening.

Results

HPV primary screening triage with p16/Ki-67 dual stain showed higher sensitivity without losing specificity compared to conventional Pap smear. The improving the screening performance leads to d

SUBMITTER: Termrungruanglert W 

PROVIDER: S-EPMC6393632 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature