Genetic variants in COL11A2 of lumbar disk degeneration among Chinese Han population.

ABSTRACT:

Background

Lumbar disk disease (LDD) is a common musculoskeletal disorder. Several predisposing genetic and environmental risk factors have been established for symptomatic LDD.

Methods

We conducted a case-control association study to investigate the role of the COL11A2 gene in LDD. Genotyping of 384 Chinese Han LDD patients and 384 Chinese Han controls was made for six single-nucleotide polymorphisms (SNPs) from COL11A2 by Agena Massarray. We evaluated these SNPs association with LDD using the chi-square test and genetic model analysis.

Results

The strongest associations with LDD were observed for polymorphisms in rs2071025. Carriers of "A" allele had an increased risk of LDD (OR = 1.47, 95% CI = 1.20-1.80, p = 0.0002) as compared with the "G" allele in allele model.

SUBMITTER: Yang X 

PROVIDER: S-EPMC6393657 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature