MicroRNA-27a and microRNA-146a SNP in cerebral malaria.

ABSTRACT:

Background

During Plasmodium falciparum infection, microRNA expression alters in brain tissue of mice with cerebral malaria compared to noninfected controls. MicroRNA regulates gene expression post-transcriptionally to influence biological processes. Cerebral malaria pathology caused mainly by the immunological disorder. We hypothesize that single-nucleotide polymorphism in a microRNA influences microRNA biogenesis or target gene recognition and altering susceptibility to cerebral malaria.

Methods

We performed a literature search based on immunological mechanism and applied microRNA-related single-nucleotide polymorphisms database to examine candidate microRNA SNPs possibly responsible for cerebral malaria. MicroRNA-27a and microRNA-146a are supposed to involve in cerebral m

SUBMITTER: Wah ST 

PROVIDER: S-EPMC6393659 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature