Proteomic analysis reveals a protective role of specific macrophage subsets in liver repair.

ABSTRACT: Macrophages are a heterogeneous population of immune cells that play central roles in a broad range of biological processes, including the resolution of inflammation. Although diverse macrophage subpopulations have been identified, the characterization and functional specialization of certain macrophage subsets in inflamed tissues remain unclear. Here we uncovered a key role of specific macrophage subsets in tissue repair using proteomics, bioinformatics and functional analysis. We isolated two hepatic monocyte-derived macrophage subpopulations: Ly6C^hiCX₃CR1^lo macrophages and Ly6C^loCX₃CR1^hi macrophages during distinct phases of acute liver injury and employed label-free proteomics approach to profile the proteome of these ce

SUBMITTER: Yang W 

PROVIDER: S-EPMC6393665 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature