Leptin receptor deficiency induces early, transient and hyperglycaemia-independent blood-brain barrier dysfunction.

ABSTRACT: Diabetes mellitus (DM) significantly increases susceptibility to central nervous system (CNS) pathologies, including stroke, vascular dementia, cognitive deficits and Alzheimer's disease. Previous studies (mostly using the streptozotocin model) suggested that blood-brain barrier (BBB) disruption is involved in these conditions. Here, we examined the integrity of brain capillaries and BBB permeability in Lepr^db/db obesity-related diabetic mice. Surprisingly, significant BBB leakage was observed only in young mice at the pre-hyperglycemic stage. Thorough examination of barrier permeability at later diabetic stages showed no evidence for significant BBB leakage during the hyperglycemic state. Electron microscopy imaging of mice with short-term hyperglycaemia supported normal BBB pe

SUBMITTER: Corem N 

PROVIDER: S-EPMC6393679 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature