Ontology highlight
ABSTRACT:
SUBMITTER: Patel N
PROVIDER: S-EPMC6393697 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
iScience 20190215
Histone deacetylases (HDACs) are promising targets for cancer therapy, although their individual actions remain incompletely understood. Here, we identify a role for HDAC2 in the regulation of MDM2 acetylation at previously uncharacterized lysines. Upon inactivation of HDAC2, this acetylation creates a structural signal in the lysine-rich domain of MDM2 to prevent the recognition and degradation of its downstream substrate, MCL-1 ubiquitin ligase E3 (MULE). This mechanism further reveals a thera ...[more]